well in anime, I guess some of the comedic characters speak Osaka ben.
South Park is dubbed with the osaka dialect in the Japanese version
My friends usually tell me that Tokyo people tend to make fun of Osaka-ben as well but I'm not sure to what extent.
Most of the Japanese comedians come from Osaka so if you want to know how it sounds like, just hear them speak.
A friend of mine lived in Osaka for awhile and he said the water was really bad