read this
QUOTE
From: Blood 94S:5b,1999 (suppl 1)
The vast majority of known G6PD mutants are single missense nucleotide
mutations. The molecularly known mutants may allow more accurate study of
population movement. G6PD mutation information about Taiwan and surrounding
countries was collected from literature. The two most common mutants in the
Han population of Taiwan, 1376G->T and 1388G->A, or their biochemically equivalent
mutants are also commonly found in Southern China, and Thailand, Vietnam,
Singapore, Laos, Malaysia, and Indonesia. The third most common mutant in
Taiwan, 493A->G, has not been found in China but is common in the Philippines
and the most common one in the Siasiat aboriginal group of Taiwan. Two other
uncommon mutants in Taiwan, 1360C->T and 487G->A, have also not been found in
China. However, 1360C->T is the most common mutant in the Philippines and is
also found in the Vanuatu islands in Melanesia. The 487G->A mutant is common
in Southeast Asian countries. Another uncommon mutant, 592C->T in Han population
is the most common one in the Ami aboriginal group. Coagulation factor VIII
(F8C)/G6PD DNA polymorphism studies suggest that Han and aboriginal groups in
Taiwan have a similar pattern suggesting they might have the same ancestors.
The same F8C/G6PD haplotype was found in 1376G->T mutants in the Taiwanese and
the Li minority in Hainan, China. G6PD deficiency is rare in Northern China
and the Northern G6PD mutants most likely originated from the South by comparing
the pattern of the haplotype of the affected patients between South and North.
The current Han populations in Taiwan and Southern China are unlikely the
descendants of Northern Chinese immigrants as family pedigree books claimed.
The current Han population in Taiwan is likely to have a partial but minor
component of ancestry from Austronesian groups. Some aboriginal groups of Taiwan
might have originally migrated from the Philippines or Taiwan is the ancestral
origin for Taiwanese aboriginal groups, Filipinos and other South Pacific Islanders
as recent studies suggest. Han in Taiwan and Southern China, minorities of
Southern China, Southeast Asians, and aboriginal groups in Taiwan probably
originate from the same ancestors, the different ones from Northern Chinese
The vast majority of known G6PD mutants are single missense nucleotide
mutations. The molecularly known mutants may allow more accurate study of
population movement. G6PD mutation information about Taiwan and surrounding
countries was collected from literature. The two most common mutants in the
Han population of Taiwan, 1376G->T and 1388G->A, or their biochemically equivalent
mutants are also commonly found in Southern China, and Thailand, Vietnam,
Singapore, Laos, Malaysia, and Indonesia. The third most common mutant in
Taiwan, 493A->G, has not been found in China but is common in the Philippines
and the most common one in the Siasiat aboriginal group of Taiwan. Two other
uncommon mutants in Taiwan, 1360C->T and 487G->A, have also not been found in
China. However, 1360C->T is the most common mutant in the Philippines and is
also found in the Vanuatu islands in Melanesia. The 487G->A mutant is common
in Southeast Asian countries. Another uncommon mutant, 592C->T in Han population
is the most common one in the Ami aboriginal group. Coagulation factor VIII
(F8C)/G6PD DNA polymorphism studies suggest that Han and aboriginal groups in
Taiwan have a similar pattern suggesting they might have the same ancestors.
The same F8C/G6PD haplotype was found in 1376G->T mutants in the Taiwanese and
the Li minority in Hainan, China. G6PD deficiency is rare in Northern China
and the Northern G6PD mutants most likely originated from the South by comparing
the pattern of the haplotype of the affected patients between South and North.
The current Han populations in Taiwan and Southern China are unlikely the
descendants of Northern Chinese immigrants as family pedigree books claimed.
The current Han population in Taiwan is likely to have a partial but minor
component of ancestry from Austronesian groups. Some aboriginal groups of Taiwan
might have originally migrated from the Philippines or Taiwan is the ancestral
origin for Taiwanese aboriginal groups, Filipinos and other South Pacific Islanders
as recent studies suggest. Han in Taiwan and Southern China, minorities of
Southern China, Southeast Asians, and aboriginal groups in Taiwan probably
originate from the same ancestors, the different ones from Northern Chinese